7-nitro-1H-imidazo[4,5-b]pyridine

7-nitro-1H-imidazo[4,5-b]pyridine - Names and Identifiers

Name	3H-Imidazo[4,5-b]pyridine, 7-nitro-
Synonyms	7-nitro-2H-iMidazo[4,5-c]pyridine 7-Nitro-2H-imidazo[4,5-d]pyridine 7-nitro-3H-iMidazo[4,5-b]pyridine 7-nitro-1H-imidazo[4,5-b]pyridine 3H-Imidazo[4,5-b]pyridine, 7-nitro- 5-chloro-7-nitro-3H-imidazo[4,5-b]pyridine
CAS	109151-82-8

7-nitro-1H-imidazo[4,5-b]pyridine - Physico-chemical Properties

Molecular Formula	C6H4N4O2
Molar Mass	164.12
Density	1.79±0.1 g/cm3(Predicted)
Boling Point	223.9±50.0 °C(Predicted)
pKa	2.67±0.20(Predicted)
Storage Condition	2-8°C

7-nitro-1H-imidazo[4,5-b]pyridine - Introduction

7-Nitro-3H-imidazo [4,5-b] pyridine (Nitroimidazopyridine) is an organic compound containing a nitro substituent. It is a yellow crystalline solid, insoluble in water at normal temperature, but soluble in organic solvents such as ethanol and dimethyl sulfoxide.

This compound has many important properties and uses. It has antibacterial, antiparasitic and antitumor activity. Especially in the field of medicine, it is widely used as a precursor of antibacterial drugs and antiparasitic drugs. It is active against a number of Gram-positive and negative bacteria, protozoa and nematodes, and exhibits specific inhibitory activity against parasites, plasmodium and amoeba.

The method for preparing 7-nitro-3H-imidazo [4,5-b] pyridine usually includes a nitration reaction and a reduction reaction. The nitration reaction can be obtained by reacting 3H-imidazo [4,5-b] pyridine with a nitrating reagent such as nitric acid. The reduction reaction is generally carried out using a reducing agent such as sodium nitrite.

When using and handling 7-nitro-3H-imidazo [4,5-b] pyridine, some safety issues need to be paid attention. This compound may be toxic to humans, irritating and allergenic. Therefore, appropriate personal protective measures should be taken during operation, such as wearing protective glasses and gloves. Its dust and solution should also avoid inhalation or contact with the skin. In addition, it is also flammable and should be kept away from open flames and heat sources. Observe relevant safety standards and procedures when storing and handling the compound.

Last Update：2024-04-09 20:52:54